Research Concept

 

Our research purpose is to create the innovative nanobioceramics and interfaces towards “Cellular Therapeutics” in biomedical fields. The studies on “(i) the nanobioceramic-induced control of cell functions through the interfacial material-cell interactions” and “(ii) the effective cellular uptakes of ligand-modified nanobioceramics” has been recently focused as shown in Figure 1.
 

Figure 1. Scheme of our research goal.

 
 
When biomaterials are implanted into our body, proteins in the body fluid are initially adsorbed and then the cells adhere to the surfaces. The adhered cell functions differently respond with different biomaterial surface properties (e.g., nanostructures, chemical composition, etc.). Therefore, I propose that the understanding of cellular response to nanobiomaterial surfaces is crucial for successful biomedical applications (e.g., tissue regeneration and integration). I have first researched how to clarify interfacial phenomena of the protein adsorption and subsequent cell adhesion using various analytical techniques (e.g., Quartz Crystal Microbalance with Dissipation (QCM-D), Atomic Force Microscopy (AFM), Fluorescent Microscopy, etc.) as shown in Figure 2. Recently, I focus on understanding the enhanced interfacial biocompatibility by explaining the role of highly-ordered nanostructures through protein-mediation. As a result, the interesting nanobiomaterials (apatite, hydrogels, and the composites) have been successfully prepared, and the different protein adsorption and cell adhesion processes have been demonstrated depending on the nanostructures. This approach clarifies several ambiguities of the interfacial phenomena between biomaterials and cells, and helps to design novel biomaterials to be implanted in the human body.
 
 

Figure 2. Scheme of our research on the nano-bio interfaces.

 
 
Incorporation of anthracene into sIlica−surfactant nanostructures were successfully achieved using a simple mechanochemical process. “solid-solid reaction”. Based on the hydrophobic interactions between micelles and anthracene, the nanocomposites showed the efficient luminescence due to the monomeric state, suggesting the mono-disperstion in the mesopores. An anticancer drug (e.g., ibuprofen etc.) with the difficult dissolution into water can be easily supported by the surfactant-silica mesostructures, and the dispersion into water is still more possible by the silica surfaces.
 

Figure 3. Scheme of the incorporation of anthracene into sIlica−surfactant nanostructures.

 
 
In future, these technologies can effectively encourage/improve the illnesses based on patient’s natural healing ability.

国立大学法人 長岡技術科学大学
大学院工学研究科 物質材料工学専攻
 

准教授

Associate Proffeser

多賀谷 基博

Motohiro TAGAYA

国立大学法人

長岡技術科学大学

大学院工学研究科 物質材料工学専攻
 
〒940-2188

新潟県長岡市上富岡町1603-1

教員居室: 物質・材料1号棟 525室
学生居室/実験室(1):博士1号棟 555室 554室 
学生居室/実験室(2):実習1号棟棟103室 116室
 

Contact

TEL : 0258-47-9345
E-mail: tagaya(at)mst.nagaokaut.ac.jp
((at)は@です)