Our research purpose is to create the innovative nanobioceramics and interfaces towards “Cellular Therapeutics” in biomedical fields. The studies on “(i) the nanobioceramic-induced control of cell functions through the interfacial material-cell interactions” and “(ii) the effective cellular uptakes of ligand-modified nanobioceramics” has been recently focused as shown in Figure 1.
When biomaterials are implanted into our body, proteins in the body fluid are initially adsorbed and then the cells adhere to the surfaces. The adhered cell functions differently respond with different biomaterial surface properties (e.g., nanostructures, chemical composition, etc.). Therefore, I propose that the understanding of cellular response to nanobiomaterial surfaces is crucial for successful biomedical applications (e.g., tissue regeneration and integration). I have first researched how to clarify interfacial phenomena of the protein adsorption and subsequent cell adhesion using various analytical techniques (e.g., Quartz Crystal Microbalance with Dissipation (QCM-D), Atomic Force Microscopy (AFM), Fluorescent Microscopy, etc.) as shown in Figure 2. Recently, I focus on understanding the enhanced interfacial biocompatibility by explaining the role of highly-ordered nanostructures through protein-mediation. As a result, the interesting nanobiomaterials (apatite, hydrogels, and the composites) have been successfully prepared, and the different protein adsorption and cell adhesion processes have been demonstrated depending on the nanostructures. This approach clarifies several ambiguities of the interfacial phenomena between biomaterials and cells, and helps to design novel biomaterials to be implanted in the human body.
Incorporation of anthracene into sIlica−surfactant nanostructures were successfully achieved using a simple mechanochemical process. “solid-solid reaction”. Based on the hydrophobic interactions between micelles and anthracene, the nanocomposites showed the efficient luminescence due to the monomeric state, suggesting the mono-disperstion in the mesopores. An anticancer drug (e.g., ibuprofen etc.) with the difficult dissolution into water can be easily supported by the surfactant-silica mesostructures, and the dispersion into water is still more possible by the silica surfaces.
In future, these technologies can effectively encourage/improve the illnesses based on patient’s natural healing ability.